Dopamine in Parkinson’s: Its Role in Speech, and Swallowing

Have you ever walked down the street, talked to a friend, and eaten an ice cream cone all at the same time without giving any of those actions a second thought? For most of us, countless actions performed throughout the day happen automatically, without conscious effort. These are not movements we decide to execute step-by-step; rather, they flow smoothly and subconsciously, thanks to intricate neural pathways that have become incredibly efficient over time. But for people with Parkinson’s, these automatic movements can become daily battles.

The key to understanding why these once-effortless actions become challenging lies in a powerful neurotransmitter in our brain: dopamine.

What Is Dopamine, and Why Is It So Important?

Dopamine, a key neurotransmitter, facilitates the planning and execution of our automatic muscle movements. Without sufficient dopamine, these actions become disrupted.

Consider every day movements such as:

  • Walking 
  • Talking 
  • Swallowing 
  • Writing 
  • Getting up from a chair

These automatic movements occur without conscious thought, and their smooth, coordinated execution relies heavily on dopamine.

How Does the Loss of Dopamine in Parkinson’s Affect Movement?

By the time symptoms appear, people with Parkinson’s have lost an estimated 60% to 80% or more of their dopamine-producing cells. This loss means that the brain struggles to produce automatic movements, leading to a range of motor challenges.  

In addition, Parkinson’s is characterized by smaller movements which impacts the ability to perform daily actions with ease. Left untreated, smaller movements, such as taking small steps while walking and taking shallow breaths while talking, can cause muscles to become weak. Parkinson’s does not directly attack muscles and make them weaker, but they can become weak simply from not being utilized to their full capacity. 

How Does the Loss of Dopamine in Parkinson’s Affect Speech & Swallowing?

The ability to speak is highly automatic. Before a diagnosis of Parkinson’s, humans regulate their volume, articulate their words, and take the appropriate amount of breath they need to communicate clearly and effectively – all without conscious effort. However, since automatic movements are highly-dependent on dopamine, the loss of dopamine in Parkinson’s leads to communication challenges. An estimated 90% of people with Parkinson’s are likely to develop a speech disorder. Common symptoms include a softer voice, gravely vocal quality, and a flat, monotone voice. Individuals may also experience rapid speech, slurring, frequent throat clearing, trailing off at the end of sentences, and difficulty in regulating their volume. It’s not unusual for someone with Parkinson’s to feel like they’re speaking loudly enough, only to be asked constantly to repeat themselves.

Dopamine loss also affects swallowing, which like speech, used to happen automatically. Challenges with swallowing may appear as drooling, coughing while eating or drinking, feeling like food or pills get stuck, and even unexplained weight loss.

If left untreated, speech disorders lead to frustration, social withdrawal, and diminished quality of life. Swallowing issues result in serious, life-threatening complications, such as aspiration pneumonia. This underscores the critical need for effective interventions that enable individuals to REGAIN and RETAIN control over their speech and swallowing. 

Overcoming Parkinson’s Dopamine Challenges Through INTENT 

While the insufficiency of dopamine significantly impacts the daily lives of people with Parkinson’s, there still exists a powerful opportunity to overcome these challenges. 

Humans have two motor systems:

  1. The Automatic Motor System: This system, being highly dependent on dopamine, causes a disruption to automatic movements when dopamine levels are low.
  2. The Intentional Motor System: This system is less dependent on dopamine. This means that when people with Parkinson’s use INTENT – when they are deliberate, focused, and purposeful – they can produce movements that appear more normal.

What does this mean for individuals with Parkinson’s? If they activate the intentional motor system:

  • They walk better.
  • They talk better.
  • They swallow better.
  • They write better 
  • They can get out of a chair better

INTENT is like a light switch that is always available. If you flip the switch, it will work. But, that’s the key. People with Parkinson’s must “flip the switch.”   

To better understand the impact of dopamine in Parkinson’s and how SPEAK OUT!® Therapy helps, watch our video: “What is Parkinson’s?” Learning to activate the intentional motor system is the key to proactively managing Parkinson’s and is the main focus of Parkinson Voice Project’s SPEAK OUT!® Therapy Program. This unique, comprehensive treatment teaches people with Parkinson’s how to convert speech from an automatic function to an intentional act. The program begins with a SPEAK OUT! Evaluation with a Certified SPEAK OUT! Provider (a speech-language pathologist who has received specialized training from Parkinson Voice Project). The evaluation is followed by individual SPEAK OUT! Therapy and daily home exercises using a SPEAK OUT! Booklet and online SPEAK OUT! Home Practice Sessions. After a month of therapy, that’s when the maintenance phase of the program begins. Weekly SPEAK OUT! Therapy Groups and regular re-evaluations help patients remain consistent with their home practice. Speech and swallowing are continuously monitored, and additional individual SPEAK OUT! Therapy is re-implemented every six to twelve months. Review our “Circle of INTENT” to better understand how SPEAK OUT! Therapy is a lifelong program. Once someone enters the program, they remain in it for the rest of their lives. Parkinson Voice Project likes to say, “We are in it with you for the long haul!”  

About The Author

Picture of Samantha Elandary, MA, CCC-SLP

Samantha Elandary, MA, CCC-SLP

The James Lowe Donnell Endowed President & CEO​

https://parkinsonvoiceproject.org/about/team/clinical/samantha-elandary/

The SPEAK OUT! Therapy Program, developed by Parkinson Voice Project, helps people with Parkinson’s and related disorders REGAIN and RETAIN their speech and swallowing. Since 2008, the nonprofit has been funded by grateful patients, their families, and community supporters.

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FAQ’s

What is the role of dopamine in Parkinson's disease?
Dopamine is crucial for facilitating the planning and execution of automatic movements. In Parkinson's disease, the degeneration of dopamine-producing cells leads to an insufficient supply, which disrupts the automatic motor system and makes daily activities challenging.
How does dopamine loss impact speech and swallowing in Parkinson's?
Dopamine facilitates the automatic planning and controlling of complex movements, including speaking and swallowing. When dopamine is lost in Parkinson's, the act of speaking is no longer automatic. It becomes difficult to control volume, articulation, and breath support for speech. If left untreated, speech disorders can lead to swallowing issues since the muscles used for speaking and swallowing are the same. The disruption of swallowing can lead to serious complications such as drooling, coughing while eating or drinking, choking, and aspiration pneumonia.
Is there a way to regain speech and swallowing abilities in Parkinson's?
Yes, individuals can regain control over speech and swallowing abilities with specialized exercises combined with the use of INTENT. By exercising the speech and swallowing muscles every day and learning to be deliberate and purposeful while speaking and eating, they can engage their brain's intentional motor system, which is less dependent on dopamine.
What is the SPEAK OUT!® Therapy Program?
Our SPEAK OUT! Therapy Program helps people with Parkinson's REGAIN and RETAIN their speech and swallowing abilities by strengthening the muscles and using INTENT. It guides them to convert speech from an automatic function to a deliberate, intentional act. The results are improved volume, articulation, vocal quality, and intonation, as well as reduced drooling and improved swallowing.
Can speech and swallowing improve even in later stages of Parkinson's?
Although early intervention of speech and swallowing issues in Parkinson’s is ideal, improvement is possible, even in later stages of Parkinson's. Family support is essential to assist with therapy and daily speech exercises.

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